Ansatz der synthetischen Biologie zur fermentativen Produktion von D-Phenylglycin

Abstract

D-phenylglycine is an industrially important non-proteinogenic amino
acid, which so far can only be produced by classical or chemo-enzymatic synthesis. Based on the new identified L-phenylglycine
biosynthetic pathway from the pristinamycin producer Streptomyces
pristinaespiralis
and a stereoinverting aminotransferase gene (hpgAT)
from Pseudomonas putida, an artificial D-phenylglycine operon was
constructed, which can be used for the fermentative production of
D-phenylglycine.

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