cofactor in cytochrome oxidase of mitochondria and many aerobic
prokaryotes is a di-copper metal center that catalyzes one-electron
transfer from cytochrome c to the oxygen-reducing active site. How the
two copper ions are brought together for assembly of
here. A thioredoxin-like disulfide reductase and two dedicated metallochaperones,
one for Cu2+ and one for Cu1+ , cooperate in this process.
Copper insertion into cytochrome oxidase proceeds by a previously