COR-101, ein menschlicher Antikörper gegen COVID-19

Abstract

COR-101 is a fully human, Fc silenced IgG that was discovered by anti-body phage display. It reduced the SARS-CoV-2 virus load in the lungby more than 99 percent in Hamster models and led to much faster recovery. Its mode of action has been elucidated by solving the atomicstructure of its interaction with SARS-CoV-2. The antibody competes with ACE2 binding by blocking a large area of the SARS-CoV-2 spike protein.

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