Coronavirus-Replikation: Mechanismus und Inhibition durch Remdesivir

Abstract

Coronaviruses use an RNA-dependent RNA polymerase to replicate and transcribe their RNA genome. The structure of the SARS-CoV-2 poly- merase was determined by cryo-electron microscopy within a short time in spring 2020. The structure explains how the viral enzyme syn- thesizes RNA and how it replicates the exceptionally large genome in a processive manner. The most recent structure-function studies furtherreveal the mechanism of polymerase inhibition by remdesivir, an approved drug for the treatment of COVID-19.

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