Cyanobakterien als Biokatalysatoren


The highly optimized natural process of oxygenic photosynthesis leads to the formation of redox equivalents, such as NADPH, that can be used to fuel heterologous biotransformations in phototrophic microorganisms. We investigated the reduction of 2-methylmaleimide by the ene-reductase YqjM in the cyanobacterium Synechocystiss sp. PCC 6803 and doubled the productivity of the cells by inactivating flavodiironproteins (FDPs) as competing electron sink under selfff- shading conditions, reaching 18.3 mmol h–1 L–1.

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