Das Potenzial von RiPPs in medizinisch-biotechnologischen Anwendungen


Ribosomally synthesized and post-translationally modified proteins
(RiPPs) are an interesting natural product superfamily. Their underlying
biosynthetic principles, where recognition sites are strictly separated
from the regions that are modified in the substrate, make them interesting
for utilization in medicinal and biotechnological applications.
Here, the promiscuity of RiPP biosynthetic enzymes will be described
for examples from the lasso and lanthipeptide subfamilies and current
developments as well as future directions in this field will be discussed.