Das Rätsel der Sphinx – Mechanismen der zellulären Sphingolipidhomöostase

Abstract

Sphingolipids are abundant and essential molecules in eukaryotes that
have crucial functions as signalling molecules and as membrane components.
They are important for many processes, including endocytic transport
and plasma membrane integrity. Pathological changes in sphingo -
lipid levels are associated with many common pathologies, ranging from
obesity and cancer to neurodegenerative diseases and genetic disorders.
Here we discuss the molecular mechanisms of cells to maintain sphingo -
lipid homeostasis.