Der Insulinrezeptor in Aktion – wie Insulin seinen Rezeptor aktiviert

Abstract

A fundamental question in signal transduction remains how the insulin
receptor transmits signals upon ligand binding across the membrane. The
overall architecture of the intact insulin receptor and its mode of activation
have been controversially debated. Using a reconstitution approach,
we were able to visualize the membrane-embedded full-length insulin
receptors by electron microscopy demonstrating its activation
mechanism.