Die Länge spezifscher Ubiquitinketten beeinfusst ihre Erkennung

Abstract

The attachment of differently linked ubiquitin (Ub) chains of varying length to proteins is a prevalent posttranslational modificationin
eukaryotic cells. We established an affinityenrichment approach for the identificationof linkage­ and length­selective ubiquitin binding
proteins and could show that in addition to the linkage, the length of a Ub chain is an important determinant for Ub chain recognition.

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