Die molekulare Entschlüsselung un konventioneller Sekretionsmechanismen

Abstract

The vast majority of secretory proteins is characterized by N-terminal signal
peptides that allow for co-translational translocation into the lumen of
the endoplasmic reticulum, the initial compartment of the classical
ER/Golgi-dependent secretory pathway. However, extracellular proteins
with fundamental physiological functions in immune surveillance and tissue
organization have been identified that lack signal peptides. The
molecular mechanisms by which these unconventional secretory proteins
reach the extracellular space are beginning to emerge.

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