DNA-Replikationsstress, Mitose und genomische Instabilität

Abstract

Chromosomal instability (CIN) is a hallmark of cancer and contributes to tumorigenesis and tumor progression. While structural CIN (S-CIN)leads to structural chromosome aberrations, whole chromosome insta-bility (W-CIN) is defined by perpetual gains or losses of chromosomesduring mitosis causing aneuploidy. Mitotic defects, but also abnormalDNA replication (replication stress) can lead to W-CIN. However, the functional link between replication stress, mitosis and aneuploidy is little understood.

Sollte Ihr Browser keine automatische Weiterleitung unterstützen, dann klicken Sie bitte hier, um das gewünschte PDF herunterzuladen.