Einblicke in die Entstehung von Mikrotubuli

Abstract

Microtubules are part of the cytoskeleton and promote various essential
cellular functions. Microtubules are dynamic polymers composed
of heterodimeric α/β-tubulin subunits and can assemble de novo in a
‘structural templating’ mechanism assisted by ring-like complexes
containing the protein γ-tubulin. Recent cryo-electron microscopy
structures of such γ--tubulin ring complexes from vertebrates propelled
our understanding of their architecture, assembly and activation
mechanism.

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