Export von Gefahrgut: Helicobacter pylori und sein CagA-Protein

Abstract

Pathogenic bacteria often utilize type IV secretion systems to interact with host cells and to modify their microenvironment in a favourable way. The human pathogen Helicobacter pylorii produces such a System to inject only a single protein, CagA, into gastric cells, but this injection represents a major risk factor for gastric cancer development. Here, we discuss the unusual structure of the Cag secretion nanomachine and
other features that make it unique among bacterial protein transporters.

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