Ferroptose: Tod durch Eisenabhängige Lipidperoxidation

Abstract

Ferroptosis is an oxidative form of necrotic cell death highly relevant for
many degenerative diseases and cancer. Ferroptosis is marked by irondependent
lipid peroxidation and is distinct from other cell death modalities.
Glutathione peroxidase 4 is the key ferroptosis player as it efficiently
controls lipid peroxidation. Transgenic mice and animal models of disease
have shown which cells and tissues are prone to undergo ferroptosis. The
discovery of novel ferroptosis inhibitors and inducers thus offers the
great potential in the development of innovative drugs to treat yet
incurable diseases.