Feste Lipidnanopartikel zur Applikation unlöslicher Wirkstoffe

Abstract

Solid lipid nanoparticles are promising carriers to improve the bio­
availability of poorly water­soluble active pharmaceutical ingredients (APIs). While the available amount of API, especially for newly identi­fiedsubstances in pharmaceutical development is often limited, the dual centrifuge ZentriMix 380 R enables the screening of up to 40 for­mulations at once in very small batches in closed vials within approxi­mately 10 minutes. Due to the included heating facility and the high stress energy induced by grinding media, lipids with melting tempera­tures of 73 °C could be processed in this study and monomodal formu­lations with particle sizes of 133 nm were achieved.