Freisetzung von Herpesviruskapsiden aus dem Kern


Herpesvirus nucleocapsids are formed in the nucleus but mature into virions
in the cytoplasm. Canonical nucleo-cytoplasmic transport is restric -
ted to the nuclear pore which is too small for passage of the ca. 120 nm
nucleocapsid. Therefore, herpesviruses use a special, vesicle-mediated
transfer by budding of nucleocapsids at the inner nuclear membrane
involving a heterodimeric viral protein complex followed by fusion with
the outer nuclear membrane. A similar cellular mechanism might exist
allowing other large cargo to leave the nucleus.