Funktion rätselhafter Retrons entschlüsselt

Abstract

VAAM-Forschungspreis 2021
Bacterial retrons are operons containing reverse transcriptases. Despite three decades of research, their physiological role remained mysterious. Recently, retrons have been uncovered as a widespread novel class of antiphage defense systems. We here discuss how high-throughput reverse genetics have enabled this discovery, illustrating the power such approaches have to illuminate the function of uncharacterized genes.

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