Funktion und Biogenese von Eisen-Schwefel-Proteinen in Eukaryoten


ron-sulfur (FeS) clusters are versatile protein cofactors that fulfil
numerous catalytic and regulatory functions in mitochondria, cytosol,
and nucleus. Maturation of FeS proteins requires the mitochondrial
iron-sulfur cluster assembly (ISC) and the cytosolic iron-sulfur protein
assembly (CIA) machineries for de novo cluster synthesis on scaffold
proteins, cluster trafficking via transfer proteins, and cluster integration
into recipient apoproteins. Here, I provide a cursory overview of
FeS protein function and maturation.