Giftspritzen mit einzigartigem Injektionsmechanismus


Tc (toxin complex) toxins are virulence factors of many insect- and
human-pathogenic bacteria. They are composed of three subunits that
act together to perforate the host membrane using a syringe-like injection
mechanism. Thereby they translocate toxic enzymes into the cell, resulting
ultimately in the death of the host cell. Our recent high-resolution
structural and functional data explain the mechanism of action of this
type of bacterial toxins in molecular detail.