HCS-Mikroskopie – ein Schlüssel zu intrazellulären Schmerzmechanismen

Abstract

Pain sensitivity is strongly modulated by intracellular signalling. The
analysis of pain signalling is hampered by small numbers of neurons, high
cellular heterogeneity, and near absence of transfectability. HCS
microscopy allowed us to proof that nociceptive neurons express specific
signalling components, to analyze signalling activity of endogenous signalling
components with single cell resolution, and thereby to suggest
blockers of Nav1.7 as novel therapeutic approach to boost the efficacy of
opioids.

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