High-content imaging für multidimensionale Zellanalysen

Abstract

Automated high-throughput microscopy has been instrumental for drug
discovery and large-scale gene perturbation screens. Advancements in
image resolution, microscope speed, and detection sensitivity have
greatly aided high-content imaging approaches. Here, we describe how
high-content microscopy can be repurposed for quantitative image-based
cytometry, an approach that exploits both the throughput and the
resolution of current screening microscopes for multidimensional cell
population analyses.