Hypoxie – Wenn weniger (Sauerstoff) mehr (Stammzellen) macht


The standard cell culture oxygen concentration of 21 percent O2 does not
represent the physiologic environment of stem cells. Indeed, hypoxic
(2) conditions heavily affect cellular processes such as
growth, apoptosis and energy metabolism. In the context of clinical trials
a fast ex vivo expansion of stem cells while maintaining their stem cell
properties is crucial. However, maintaining hypoxic conditions during
cultivation is challenging and puts high requirements on laboratory

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