Insulin und sein Rezeptor – Spezifität durch Kombinatorik?


Glucose homeostasis and growth essentially depend on insulin engaging
its receptor. Combining biochemistry, structural biology, and
molecular dynamics simulations, we demonstrated how insulin binding
stabilizes the insulin receptor in a T-shaped conformation with up to
four bound ligands: two at receptor site 1 and – for the first time – two
at site 2. These findings expand the current models of insulin binding
to its receptor and potentially inform new approaches to structure-
guided drug design.