Karzinogenese: Big Bang oder kontinuierliche Evolution?

Abstract

Intra-tumour heterogeneity is a key characteristic of tumours and
poses significant clinical challenges. Despite extensive research, the evolutionary processes shaping cancer genomes are not yet fully
understood. We here discuss two conflicting theories about the
evolution of solid tumours: the Big Bang model and the classical model of continuous evolution. Using chromosomal instability we shed lighton the preferred mode of cancer evolution and its implications for
personalised treatment.

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