Loops und Tunnel: unterschätzte Elemente in Enzymen


In enzymes, the active site is the location where substrates are chemically
converted. If this site is deeply buried within the protein, substrates
must pass not only through the body of the protein via a tunnel,
but also flexible, site-decorating loops to access the active site. These
elements can act as filters that influence on both substrate specificity
and activity. Identifying and understanding how they exert such control
has been of growing interest over the past several years.