Markerfreie Karyotypisierung von Chromosomen durch spektrales Imaging

Abstract

Karyotyping is currently based on staining techniques. These methods
lack reproducibility, are time-consuming and require complex expert
knowledge. This paper introduces a new marker-free, fully automated and
reliable screening procedure for chromosomes. The method is based on
multimodal, spatially resolved spectroscopy combined with multivariate
data analysis and can easily be integrated into a standard light microscope.

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