Maßgeschneiderte Polyketidsynthasen zur Herstellung von Polyketid-Derivaten

Abstract

Polyketides (PKs) are secondary metabolites with valuable properties,
including antibiotic, antifungal, antiviral, anticancer, and immunosuppressive
activity. The biosynthesis of PKs is accomplished by multifunctional
megaenzymes, the polyketide synthases (PKSs). The molecular
architecture of those remarkable assembly lines provides opportunities
for their engineering and generation of PK derivatives with
potentially improved pharmacokinetics and/or expanded spectrum of
bioactivity.

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