Mechanismen und Funktionen von bakteriellen AAA+-Entfaltungsmaschinen

Abstract

Bacterial AAA+ proteins play crucial roles in proteostasis networks andensure protein homeostasis during stress conditions. They function as ATP-dependent components of proteolytic complexes degrading mis-folded proteins or as disaggregases reactivating aggregated proteins.AAA+ proteins generate an ATP-fueled threading force driving substrateunfolding and translocation. Their central functions in protein qualitycontrol qualify them as antibacterial drug target.

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