Membranproteinfaltung – Kernwissen aus (nicht zu) vereinfachten Systemen


Despite their functional and structural diversity, membrane proteins of all
living cells are inserted and assembled via a few evolutionary conserved
pathways. Here, we describe how studies in model membranes provide
insights into the functionality of the Sec translocon, a primary machinery
for the insertion of a-helical membrane proteins, but also for translocation
of unfolded polypeptide chains across the membrane. To bring
together in vitro and in vivo analysis, further developments of new
membrane mimetics are suggested.