Modulation von Proteinfunktion mit Alpaka-Nanobodies in lebenden Zellen

Abstract

New genetic tools allow the disruption of every single gene. Yet, we only
have limited tools to target biological processes at the protein level.
Alpaca nanobodies can modulate and visualize protein function in living
cells. This article describes a functional screening approach that identifies
nanobodies based on the phenotype they elicit when expressed in the
cytosol. In principle, this approach will allow the identification of specific
activators and inhibitors of any biological pathway.

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