N-Hydroxydiamine – vielseitige Bausteine für Wirkstoffsynthesen


An enzymatic cascade from ω-amino amino acids towards monohydroxylated
α,ω--diamines gives highly interesting materials for processing
into fine chemicals. With two simple UV-vis spectroscopy-based
screening methods, enzyme candidates with a compatibility window to
perform a three-enzyme cascade from lysine and ornithine to the
desired products were identified. The results give first insight into the
feasibility of the desired cascade and put handles on future reaction
engineering tasks.