Neue Einblicke in die Entstehung von komplexen Karyotypen bei Krebs

Abstract

Cancer cells differ from healthy cells by massively altered genomes. This
includes point mutations as well as chromosomal rearrangements and
changes in chromosome numbers. Novel in vitro models mimic chromosomal
aberrations and allow their systematic analysis. Here we present
recent findings how changes in chromosome numbers and their structure
alter physiology of human cells and instigate further genomic instability,
thus recapitulating the processes that occur during tumorigenesis.