Neue Krankheiten mit Bluttranskriptomik entschlüsseln

Abstract

The COVID-19 pandemic is leading to increasing numbers of patients all over the world. Reports on dysregulated immune system in the severe cases calls for a better characterization of the ongoing changes. To dissect COVID-19-driven immune host responses, we profiled whole blood transcriptomes enabling a data driven stratification based on molecular phenotype. This analysis allowed prediction of patient subgroup-specific drug candidates targeting the dysregulated systemic immune response of the host.

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