Neue Möglichkeiten für die Strukturbestimmung von Membranproteinen


Membrane proteins establish the connection between the outside and
the inside of a cell. Even though 30 percent of proteins in a cell are membrane associated, their structural data is strongly underrepresented
due to the high flexibility and low purification yield. The resolution revolution in cryo-EM opened up new opportunities to solve structures of dynamic membrane proteins that can only be purified in small quantities.