Ordnung am Ribosom – der multifunktionale Komplex NAC

Abstract

Newly synthesized proteins are processed by a variety of ribosomeassociated
factors that regulate cotranslational protein folding, transport
and degradation. How these competing factors gain regulated and
timely access to ribosomes and specific nascent substrates is poorly
understood. Recent studies identified a key factor in eukaryotes that
coordinates multiple cotranslational events at the ribosomal tunnel
exit – the nascent polypeptide-associated complex (NAC).

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