Phagentaxonomie in der Next Generation Sequencing-Ära

Abstract

Phages are the biggest known biological entity on earth (about 1031 particles). Due to next generation
sequencing methods applied on environmental samples an unpreceeded amount of phage genome data is
available. Due to their extreme diversity and the lack of monophyly a sequence based taxonomy is challenging.
However, within the phages there are monophyletic subgroups that can be classified based on their
genome sequence. A method that combines the shared gene content with taxon specific similarities enables
a reliable identification of the phage family based exclusively on the corresponding genome sequence.

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