Plasmazellüberleben wird durch extrinsische Signale reguliert


Secreted antibodies form the basis for protective vaccination, the
most effective method of disease control to date. Plasma cells are the
main producers of antibodies. A single plasma cell can secrete thousands
of antibodies per second and thus forms the basis of humoral
immunity of the body. While this function plays an important role to
protect the body from recurring pathogens, autoreactive plasma cells
secreting autoantibodies can lead to severe organ damage in diseases
such as rheumatoid arthritis and systemic lupus erythematosus.