R-Spondine: Einblicke in die Potenzierung der Wnt-Signaltransduktion

Abstract

Intercellular signalling by Wnt morphogenetic proteins is subject to a
multi-layered system of regulation. The four secreted R-spondin proteins
potentiate Wnt signalling in vertebrates. They are involved in embryogenesis,
adult stem cell biology and cancer progression and have been
proven essential for ex vivo culturing of organoids. Recent research has
generated profound new insights into how R-spondins function to stabilize
Wnt receptors of the Frizzled family at the cell surface.

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