Regulation der Chaperonaktivität im endoplasmatischen Retikulum


Maintenance of protein homeostasis depends on cellular stress
response pathways that mediate adaptive changes in gene expression.In the endoplasmic reticulum additional mechanisms adjust the availability of the abundant Hsp70-type chaperone, BiP, during short-term
fluctuations in the unfolded protein load. Here, recent insights into theregulation of BiP by incorporation into inactive oligomers and reversible AMPylation are discussed.