Regulation des Angstverhaltens – zur Rolle neuronaler Netzwerke


The corticotropin-releasing hormone (CRH) system orchestrates the
organism’s stress response including the regulation of adaptive be -
haviours. Here we describe a novel neuronal circuit, which acts anxiety
suppressing and positively modulates dopamine release. This anxiolytic
circuit comprises inhibitory CRH-expressing, long-range projection neurons
within the extended amygdala. These neurons innervate the ventral
tegmental area, a prominent brain reward center that expresses high
levels of CRH receptor type 1.