Rho-Signalgebung in der Tumorentstehung und -progression

Abstract

Metastatic cancers are characterized by uncontrolled cell proliferation
and tissue invasion, processes controlled by small Rho GTPases, the activation
of which is regulated by GEF and GAP proteins. Deleted in liver cancer
(DLC) proteins are such Rho regulators that are downregulated in different
types of cancer. Using proteomic approaches, genetically encoded
biosensors and high resolution microscopy, our lab studies how the DLC
proteins control cellular Rho activity patterns in time and space.

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