Same same but different: Wie Cyanobakterien ein zentrales Enzym regulieren


In most bacteria the activity of glutamine synthetase (GS) is regulated by
covalent protein modifications. Remarkably, cyanobacteria, which are of
increasing interest in biotechnology, have evolved fundamentally different
regulatory mechanisms for the same enzyme. This includes GS inhibition
by the interaction with small proteins, the inactivating factors (IF). In
addition, they evolved unique mechanisms to monitor GS activity and to
respond with IF biosynthesis accordingly.