Sekretion von Galektin-3 – Blaupause für die Freisetzung behüllter Viren?

Abstract

In the classical view secreted proteins are synthesized at the ER and
traverse the Golgi before being released into the extracellular medium at
the cell surface. However, substantial number of polypeptides utilize
alternative non-classical secretion following initial synthesis in the cytoplasm.
Among them is galectin-3, which mediates numerous physiological
functions in the extracytosolic milieu. Here, we discuss the molecular
mechanism by which galectin-3 enters exosomes for secretion in association
with the ESCRT-component Tsg101.