Stop and go: Oocyten auf ihrem Weg zu einer befruchtungsfähigen Eizelle


Fertilization, the fusion of the female and male gamete, is the initiating
event for the development of any sexually-reproducing organism. The
production of haploid gametes involves two consecutive meiotic divisions
during which the diploid genome is reduced to half, creating four
haploid cells. Here, we discuss how the interplay of dynamic protein
phosphorylation and irreversible protein degradation drives meiotic
cell cycle regulation in vertebrate oocytes.