Stress macht Zellen resistent gegen Folsäure-basierte Chemotherapeutika


The unfolded protein response (UPR), a cellular stress response path-way, is broadly implicated in disease and resistance to therapy. The
molecular mechanisms that drive stress-mediated chemoresistanceare, however, only poorly understood. We have employed a multiomics approach to determine UPR-induced gene regulation, revealingthe UPR regulon. We further observe metabolic rewiring upon stressand resistance to Methotrexate, a widelyyy-employed therapeutic reagent.The precise molecular characterization of the pathway driving resistance might lead to novel concepts in cancer therapy.