Synthetische subzelluläre Kompartimente in eukaryotischen Zellen


Genetic engineering of metabolic pathways for biotechnological purposes
is often hampered by factors like slow diffusion rates, competing pathways
or secretion of intermediates. To bypass these limitations, compartimentalization
of enzymatic reactions is a promising approach. For this,
enzymes can either be arranged in complexes or they can be isolated in
coated subcellular compartments. We are developing new concepts to
assemble various enzymes in protein supercomplexes and to relocate
metabolic pathways into synthetic organelles.

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