Trans-agierende Attenuator-RNA und Leaderpeptid in Bakterien


Bacterial transcription attenuators are a source of small RNAs (sRNAs) and leader peptides, for which no own functions were known. However, the attenuator sRNA of the tryptophan (Trp) biosynthesis operonregulates gene expression in trans according to the Trp-availability. Moreover, the cognate leader peptide adopted Trp-independent functions. It builds antibiotic-dependent ribonucleoprotein complexes(ARNPs) for sRNA reprogramming and regulation of ribosomal and multiresistance genes.

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