Yin und Yang beim Lernen im jungen Gehirn: Balance von PSD-95 und PSD-93


During development, there are restricted time windows (critical
periods) in which the juvenile brain is particularly plastic and gets
optimized in an activity-dependent way. The balance between two
signalling scaffold proteins of excitatory synapses with opposing
functions is essential for both synapse maturation and the timing of
critical periods. We hope that our new results will help to develop
strategies for rehabilitation after brain lesions and for treating
neurodevelopmental disorders.