Zyklische Dinukleotide als molekulare Entwicklungsbremse


Streptomyces are renowned producers of antibiotics and other medically useful molecules. They undergo a developmental life cycle involving pro­gression from vegetative growth to the erection of reproductive aerial
hyphae, which differentiate into chains of spores. The second messen­
gers c­di­GMP and c­di­AMP control this complex morphological transi­
tion. Studies on signalling mechanisms in this bacterial model led to the discovery of a tetrameric c­di­GMP, a sigma factor as an unexpected type of c­di­GMP effectors and a new class of c­di­AMP phosphodiesterases.